Foresight’s principal focus has been the development of advanced nanotechnology for atomically precise manufacturing, but the incremental development and application of current nanotechnology is also a major interest . Meeting the challenges of incremental nanotechnology development and application includes adequately addressing any potential environmental, health, and safety issues (see Foresight’s “ Nanoparticle safety ” policy brief .). We therefore note with pleasure that an expert panel of the National Academy of Sciences has recommended that the potential health and environmental risks of nanomaterials should be studied further and that they will revisit the issue in 18 months, when it is to be hoped that the necessary research will be moving forward. From “ With Prevalence of Nanomaterials Rising, Panel Urges Review of Risks ” by Cornelia Dean: … Nanoscale forms of substances like silver, carbon, zinc and aluminum have many useful properties. Nano zinc oxide sunscreen goes on smoothly, for example, and nano carbon is lighter and stronger than its everyday or “bulk” form. But researchers say these products and others can also be ingested, inhaled or possibly absorbed through the skin. And they can seep into the environment during manufacturing or disposal. Nanomaterials are engineered on the scale of a billionth of a meter, perhaps one ten-thousandth the width of a human hair, or less. Not enough is known about the effects, if any, that nanomaterials have on human health and the environment, according to a report issued by the academy’s expert panel. The report says that “critical gaps” in understanding have been identified but “have not been addressed with needed research.” And because the nanotechnology market is expanding — it represented $225 billion in product sales in 2009 and is expected to grow rapidly in the next decade — “today’s exposure scenarios may not resemble those of the future,” the report says. The panel called for a four-part research effort focusing on identifying sources of nanomaterial releases, processes that affect exposure and hazards, nanomaterial interactions at subcellular to ecosystem-wide levels and ways to accelerate research progress. … A free PDF of the report A Research Strategy for Environmental, Health, and Safety Aspects of Engineered Nanomaterials is available. —James Lewis
Archive for February, 2012
Panel recommends research to manage health and environmental risks of nanomaterials
Will 3D printers lead toward nanofactories?
The coming era of atomically precise manufacturing will provide digital control of the structure of matter for a very wide range of possible products and will make possible personal manufacturing of most products. Steps toward digital control of the structure of matter and personal manufacturing, although on a scale much less precise than atomic and for a much more limited range of products, are to be seen with today’s rapidly developing 3D-printing technology. Rival technologies were on display a few weeks ago in Las Vegas. From BBC News “ CES 2012: 3D printer makers’ rival visions of future ” by Leo Kelion: With a whir and a click the job is done. In the space of 20 minutes a plastic bottle opener has been constructed by the Replicator – a 3D printing machine capable of making objects up to the size of a loaf of bread. The device is made by the New York start-up Makerbot Industries and was launched this week at the Consumer Electronics Show in Las Vegas. The newly-created bottle opener feels warm to the touch and has to be prised away from its base. It has been created by using extrusion technology – a process in which a spindle of plastic thread is unravelled, melted and fed through a print head which draws the object layer by layer – in this case at a rate of 40mm per second. … Objects can be created on a computer using free online software such as TinkerCAD or Google Sketchup, before being transferred to the Replicator on a SD memory card. Alternatively other people’s designs can be downloaded from Makerbot’s community website Thingiverse. … Take a walk to the other side of the convention centre and you will find another plastic printer maker with another new product, but a very different way of thinking. 3D Systems is a North Carolina-based veteran of the business. “We invented 3D printers,” its Israeli-born chief executive Abe Reichental says. “For 25 years we have taken the classic journey of taking expensive, complex technology and bringing it down in price. “We have about 1,000 workers worldwide. We are a publicly traded company on the New York Stock Exchange. We have almost as many patents as employees.” The firm is at CES to publicise the launch of Cube, its first consumer-focused product. The $1,299 device is smaller than Makerbot’s but looks more user-friendly, utilising cartridges rather than spools of plastic thread. It also boasts its own app store. The launch library includes software to customise belt buckles, a program to turn your voice into a bracelet design, and perhaps most excitingly software from developer Geomagic for Microsoft’s Kinect sensor that allows the peripheral to replicate the user’s face. … Philippe Van Nedervelde, Foresight’s Executive Director-Europe, contributes his thoughts on the significance of current developments in 3D printers, Check out: – http://www.youtube.com/watch?v=jLgZL0OAJhg – http://cubify.com/ – http://fabbaloo.com/blog/2012/1/6/secret-cubify-project-to-be-unveiled.html The era of Personal 3D Printing for consumers [has officially started], it seems. And what with its existing track record of excellence plus the slew of key 3D printing companies it has been buying up the company 3D Systems is well poised to become the IBM, Apple, or HP of this new space. (25 years from now, someone should kick me if I do not buy any shares now.) My sense is that this launch is a close analog to the start-of-an-era-marking launch of the first PC by IBM on August 12, 1981. In some ways, a possibly even closer analog may be the launch of the original Mac on January 24, 1984. Very interesting times ahead!… ~ Philippe ~ Perhaps Philippe is not exaggerating the significance of this emerging personal manufacturing technology. Personal manufacturing of plastic consumer items may accelerate developing productive nanosystems to make possible personal manufacturing of complex atomically precise consumer products. —James Lewis
DNA motor navigates network of DNA tracks
The structural DNA path toward productive nanosystems has achieved another step forward with the demonstration that a DNA origami scaffolding can be used to program a DNA motor to navigate a network of tracks. A hat tip to PhysOrg.com for reprinting this news release from Kyoto University “ DNA Motor Programmed to Navigate a Network of Tracks “: Kyoto, Japan — Expanding on previous work with engines traveling on straight tracks, a team of researchers at Kyoto University and the University of Oxford have successfully used DNA building blocks to construct a motor capable of navigating a programmable network of tracks with multiple switches. The findings, published in the January 22 online edition of the journal Nature Nanotechnology [ abstract ], are expected to lead to further developments in the field of nanoengineering. The research utilizes the technology of DNA origami, where strands of DNA molecules are sequenced in a way that will cause them to self-assemble into desired 2D and even 3D structures. In this latest effort, the scientists built a network of tracks and switches atop DNA origami tiles, which made it possible for motor molecules to travel along these rail systems. “We have demonstrated that it is not only possible to build nanoscale devices that function autonomously,” explained Dr. Masayuki Endo of Kyoto University’s Institute for Integrated Cell-Material Sciences (iCeMS), “but that we can cause such devices to produce predictable outputs based on different, controllable starting conditions.” The team, including lead author Dr. Shelley Wickham at Oxford, expects that the work may lead to the development of even more complex systems, such as programmable molecular assembly lines and sophisticated sensors. “We are really still at an early stage in designing DNA origami-based engineering systems,” elaborated iCeMS Prof. Hiroshi Sugiyama. “The promise is great, but at the same time there are still many technical hurdles to overcome in order to improve the quality of the output. This is just the beginning for this new and exciting field.” Courtesy Sugiyama Lab, Kyoto University iCeMS A depiction of a DNA origami tile with a built-in network of tracks. The DNA engine or motor, in red, can be programmed to navigate a series of junctions to reach one of four desired end points. Perhaps the next step is to have multiple addressable DNA motors bring different components together to be joined? —James Lewis
Current nanotechnology too cool to ignore
For something a little different from our usual fare, the superhydrophobic spray-on coating illustrated in this YouTube video is too cool to ignore: Ross Nanotechnology’s NeverWet superhydrophobic spray-on coating . A white tennis shoe protected with their fabric coating remained spotless as heavy chocolate syrup poured on the shoe raced away. The video caption says consumer products will be available in early 2012, but the NeverWet web site seems focused on industrial partnerships for various applications, like anti-icing and anti-corrosion coatings. As someone too clumsy to avoid stains and too lazy to clean them, I could grow to like a fabric spray. Their anti-bacterial coatings could be especially useful in minimizing the spread of drug-resistant bacteria. —James Lewis
Graphene heterostructures may lead to graphene-based computer chips
Tunnelling transistor Tunnelling transistor based on vertical graphene heterostructures. Tunnelling current between two graphene layers can be controlled by gating. Credit: University of Manchester . L. Britnell et al. Science DOI: 10.1126/science.1218461 Combining atomically thin graphene with layers of atomically thin insulators appears to open the door to using graphene in computer chips. A hat tip to KurzweilAI.net for reprinting this University of Manchester news release “ Graphene electronics moves into a third dimension “: Wonder material graphene has been touted as the next silicon, with one major problem—it is too conductive to be used in computer chips. Now scientists from The University of Manchester have given its prospects a new lifeline. In a paper published this week in Science [ abstract ], a Manchester team lead by Nobel laureates Professor Andre Geim and Professor Konstantin Novoselov has literally opened a third dimension in graphene research. Their research shows a transistor that may prove the missing link for graphene to become the next silicon. Graphene—one atomic plane of carbon—is a remarkable material with endless unique properties, from electronic to chemical and from optical to mechanical. One of many potential applications of graphene is its use as the basic material for computer chips instead of silicon. This potential has alerted the attention of major chip manufactures, including IBM, Samsung, Texas Instruments and Intel. Individual transistors with very high frequencies (up to 300 GHz) have already been demonstrated by several groups worldwide. Unfortunately, those transistors cannot be packed densely in a computer chip because they leak too much current, even in the most insulating state of graphene. This electric current would cause chips to melt within a fraction of a second. … The University of Manchester scientists now suggest using graphene not laterally (in plane)—as all the previous studies did—but in the vertical direction. They used graphene as an electrode from which electrons tunnelled through a dielectric into another metal. This is called a tunnelling diode. Then they exploited a truly unique feature of graphene—that an external voltage can strongly change the energy of tunnelling electrons. As a result they got a new type of a device—vertical field-effect tunnelling transistor in which graphene is a critical ingredient. Dr Leonid Ponomarenko, who spearheaded the experimental effort, said: “We have proved a conceptually new approach to graphene electronics. Our transistors already work pretty well. I believe they can be improved much further, scaled down to nanometre sizes and work at sub-THz frequencies.” … The Manchester team made the transistors by combining graphene together with atomic planes of boron nitride and molybdenum disulfide. The transistors were assembled layer by layer in a desired sequence, like a layer cake but on an atomic scale. Such layer-cake superstructures do not exist in nature. It is an entirely new concept introduced in the report by the Manchester researchers. The atomic-scale assembly offers many new degrees of functionality, without some of which the tunnelling transistor would be impossible. “The demonstrated transistor is important but the concept of atomic layer assembly is probably even more important,” explains Professor Geim. Professor Novoselov added: “Tunnelling transistor is just one example of the inexhaustible collection of layered structures and novel devices which can now be created by such assembly. “It really offers endless opportunities both for fundamental physics and for applications. Other possible examples include light emission diodes, photovoltaic devices, and so on.” Graphene is one area of nanotechnology that is generating both increased scientific rewards and increased application potential as work continues. It provides an example of the opportunities that can be opened by an apparently serendipitous discovery. It is also an indication of the rich rewards that are to be found from approaching atomic precision in the control of the structure of matter. —James Lewis
Combined strategies of apomorphine diester prodrugs and nanostructured lipid carriers for efficient brain targeting
Our aim is to develop nanostructured lipid carriers (NLCs) for loading the apomorphine diester prodrugs, diacetyl apomorphine (DAA) and diisobutyryl apomorphine (DIA), into the brain. NLCs were prepared using sesame oil/cetyl palmitate as the lipid matrices. Experiments were performed with the objective of evaluating the physicochemical characteristics, drug release, safety and brain-targeting efficacy of the NLCs. The size of regular NLCs (N-NLCs) was 214 nm. The addition of Forestall (FE) and polyethylene glycol (PEG) to the NLCs (P-NLCs) increased the particle diameter to 250 nm. The zeta potentials of N-NLCs and P-NLCs were respectively shown to be − 21 and 48 mV. Diester prodrugs were more lipophilic and more chemically stable than the parent apomorphine. The hydrolysis study indicated that the prodrugs underwent bioconversion in plasma and brain extract, with DAA exhibiting faster degradation than DIA. Sustained release was achieved through the synergistic effect of integ…
Quantum interferential Y-junction switch
We report the observation of the Fermi energy controlled redirection of the ballistic electron flow in a three-terminal system based on a small (100 nm) triangular quantum dot defined in a two-dimensional electron gas (2DEG). Measurement shows strong large-scale sign-changing oscillations of the partial conductance coefficient difference G 21 − G 23 on the gate voltage in zero magnetic field. Simple formulas and numerical simulation show that the effect can be explained by quantum interference and is associated with weak asymmetry of the dot or inequality of the ports connecting the dot to the 2DEG reservoirs. The effect may be strengthened by a weak perpendicular magnetic field. We also consider an additional three-terminal system in which the direction of the electron flow can be controlled by the voltage on the scanning gate microscopy (SGM) tip.
A combination of capillary and dielectrophoresis-driven assembly methods for wafer scale integration of carbon-nanotube-based nanocarpets
The wafer scale integration of carbon nanotubes (CNT) remains a challenge for electronic and electromechanical applications. We propose a novel CNT integration process relying on the combination of controlled capillary assembly and buried electrode dielectrophoresis (DEP). This process enables us to monitor the precise spatial localization of a high density of CNTs and their alignment in a pre-defined direction. Large arrays of independent and low resistivity (4.4 × 10 −5 Ω m) interconnections were achieved using this hybrid assembly with double-walled carbon nanotubes (DWNT). Finally, arrays of suspended individual CNT carpets are realized and we demonstrate their potential use as functional devices by monitoring their resonance frequencies (ranging between 1.7 and 10.5 MHz) using a Fabry–Perot interferometer.
Effect of top-down nanomachining on electrical conduction properties of TiO 2 nanostructure-based chemical sensors
The present research was motivated by the growing interest of the scientific community towards the understanding of basic gas–surface interaction mechanisms in 1D nanostructured metal oxide semiconductors, whose significantly enhanced chemical detection sensitivity is known. In this work, impedance spectroscopy (IS) was used to evaluate how a top-down patterning of the sensitive layer can modulate the electrical properties of a gas sensor based on a fully integrated nanometric array of TiO 2 polycrystalline strips. The aim of the study was supported by comparative experimental activity carried out on different thin film gas sensors based on identical TiO 2 polycrystalline sensitive thin films. The impedance responses of the investigated devices under dry air (as the reference environment) and ethanol vapors (as the target gas) were fitted by a complex nonlinear least-squares method using LEVM software, in order to find an appropriate equivalent circuit describ…
Thermal stability of embedded metal nanoparticles elongated by swift heavy ion irradiation: Zn …
Solid Zn and V nanoparticles (NPs) embedded in silica were elongated by swift heavy ion (SHI) irradiation with 200 MeV Xe 14+ ions to a fluence of 5.0 × 10 13 ions cm −2 . Isochronal annealing was carried out in a vacuum from 200 to 1000 °C in steps of 100 °C for 10 min each. The degree of shape elongation was evaluated at room temperature (RT) by two different optical methods: linear dichroism spectroscopy and birefringence spectroscopy. In the as-irradiated state, the samples showed an absorption band at 5 eV due to radiation-induced defects in the silica in addition to the anisotropic absorption due to the elongated metal NPs. After annealing at 400 °C the defect band had completely disappeared, while the degree of shape elongation was almost unchanged or rather slightly increased in both the Zn and V NPs. The elongation of the Zn NPs slightly decreased but maintained a certain value after annealing at 500 °C, which is much higher than the melting …



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