Posts Tagged ‘Research’

Mounting graphene on boron nitride improves its electronic properties

When a sheet of graphene sits atop a sheet of boron nitride at an angle, a secondary hexagonal pattern emerges that determines how electrons flow across the sample. (Illustration by Brian LeRoy) Despite its superlative properties, graphene has not been used to make electronic devices because electrons travel so well though it that they cannot be easily controlled. Now physicists have discovered that placing graphene sheets on boron nitride at the proper angle creates a superlattice that controls the movement of graphene electrons. A hat tip to ScienceDaily for reprinting this University of Arizona news release written by Daniel Stolte “ Microprocessors From Pencil Lead “: Graphite, more commonly known as pencil lead, could become the next big thing in the quest for smaller and less power-hungry electronics. Resembling chicken wire on a nano scale, graphene – single sheets of graphite – is only one atom thick, making it the world’s thinnest material. Two million graphene sheets stacked up would not be as thick as a credit card. The tricky part physicists have yet to figure out how to control the flow of electrons through the material, a necessary prerequisite for putting it to work in any type of electronic circuit. Graphene behaves very different than silicon, the material currently used in semiconductors. Last year, a research team led by UA physicists cleared the first hurdle by identifying boron nitride, a structurally identical but non-conducting material, as a suitable mounting surface for single-atom sheets of graphene. The team also showed that in addition to providing mechanical support, boron nitride improves the electronic properties of graphene by smoothening out fluctuations in the electronic charges. Now the team found that boron nitride also influences how the electrons travel through the graphene. Published in Nature Physics [ abstract ], the results open up new ways of controlling the electron flow through graphene. “If you want to make a transistor for example, you need to be able to stop the flow of electrons,” said Brian LeRoy, an assistant professor in the University of Arizona’s department of physics. “But in graphene, the electrons just keep going. It’s difficult to stop them.” … However, as LeRoy’s group has now discovered, mounting graphene on boron nitride prevents some of the electrons from passing to the other side, a first step toward a more controlled electron flow. The group achieved this feat by placing graphene sheets onto boron nitride at certain angles, resulting in the hexagonal structures in both materials to overlap in such a way that secondary, larger hexagonal patterns are created. The researchers call this structure a superlattice. If the angle is just right, they found, a point is reached where almost no electrons go through. The news release points out that the researchers cannot yet control the angle at which the graphene and boron nitride are oriented so that only 10-20% of the samples they make show the desired effect. This process must be automated before graphene electronics become practical. —James Lewis, PhD

Miniature Pressure Sensors

. A new kind of flexible, transparent pressure sensor, developed at the University of California, Davis, for use in medical applications, relies on a drop of liquid. The droplet goes in a flexible sandwich of the substance polydimethylsiloxane, or PDMS . The sensor acts as a variable electrical capacitor. When the sensor is pressed down, the sensing droplet is squeezed over conductive electrodes, increasing its capacitance. “There’s a huge need for flexible sensors in biosensing,” said Professor Tingrui Pan, who led the research project. He and his colleagues used the sensor successfully in measuring the pulse in the human neck. The sensor also could be used in “smart gloves,” giving physicians an enhanced ability to measure the firmness of tissues and detect tumors, and in “smart contact lenses,” to monitor intraocular pressure without affecting vision. Read More Paper

Faster, less expensive medical diagnostics through nanotechnology

Image courtesy of Oregon State University Artistic representation of a carbon nanotube and two protein molecules. Nanomedicine will make major contributions to health care not only by providing new and improved therapies, but by providing new diagnostic methods that will be faster and less expensive than currently available procedures. A hat tip to KurzweilAI News for reprinting this news release from Oregon State University “ Nanotube technology leading to fast, lower-cost medical diagnostics “: Researchers at Oregon State University have tapped into the extraordinary power of carbon “nanotubes” to increase the speed of biological sensors, a technology that might one day allow a doctor to routinely perform lab tests in minutes, speeding diagnosis and treatment while reducing costs. The new findings have almost tripled the speed of prototype nano-biosensors, and should find applications not only in medicine but in toxicology, environmental monitoring, new drug development and other fields. The research was just reported in Lab on a Chip [ abstract ], a professional journal. More refinements are necessary before the systems are ready for commercial production, scientists say, but they hold great potential. “With these types of sensors, it should be possible to do many medical lab tests in minutes, allowing the doctor to make a diagnosis during a single office visit,” said Ethan Minot, an OSU assistant professor of physics. “Many existing tests take days, cost quite a bit and require trained laboratory technicians. “This approach should accomplish the same thing with a hand-held sensor, and might cut the cost of an existing $50 lab test to about $1,” he said. The key to the new technology, the researchers say, is the unusual capability of carbon nanotubes. An outgrowth of nanotechnology, which deals with extraordinarily small particles near the molecular level, these nanotubes are long, hollow structures that have unique mechanical, optical and electronic properties, and are finding many applications. In this case, carbon nanotubes can be used to detect a protein on the surface of a sensor. The nanotubes change their electrical resistance when a protein lands on them, and the extent of this change can be measured to determine the presence of a particular protein – such as serum and ductal protein biomarkers that may be indicators of breast cancer. The newest advance was the creation of a way to keep proteins from sticking to other surfaces, like fluid sticking to the wall of a pipe. By finding a way to essentially “grease the pipe,” OSU researchers were able to speed the sensing process by 2.5 times. Further work is needed to improve the selective binding of proteins, the scientists said, before it is ready to develop into commercial biosensors. “Electronic detection of blood-borne biomarker proteins offers the exciting possibility of point-of-care medical diagnostics,” the researchers wrote in their study. “Ideally such electronic biosensor devices would be low-cost and would quantify multiple biomarkers within a few minutes.” The above news item indicates not only how nanotechnology is going to improve medical care, but it hints at the future economic impact of widespread nanotechnology. If a five-minute test using a handheld biosensor in the doctor’s office replaces several expensive lab tests performed by skilled technicians, what happens to the jobs of those technicians? Historically technological innovation has created more and better jobs than those that were lost, and in this case the expanding nanotechnology industry may create jobs for the displaced medical lab technicians. But it is not at all clear that this trend will persist with the more radical displacements that will occur as nanotechnology advances toward productive nanosystems and atomically precise manufacturing. As early as 1986 in Engines of Creation Eric Drexler described how advanced nanotechnology and artificial intelligence could produce a world of abundance with no need of human labor and proposed an Inheritance Day to distribute the wealth. Three years ago here on Nanodot J Storrs Hall described how artificial general intelligence could produce an “early retirement” for the human race (see “ Early retirement ” and “ Early retirement — how soon? “). Perhaps the issue of how transformative technologies will affect jobs, employment, and the distribution of wealth deserves more attention. —James Lewis, PhD

Nanostructured adhesive can hold up to 700 pounds on glass

Photo and description courtesy of UMass Amherst “A card-sized pad of Geckskin can firmly attach very heavy objects such as this 42-inch television weighing about 40 lbs. (18 kg) to a smooth vertical surface. The key innovation by Bartlett and colleagues was to create a soft pad woven into a stiff fabric that includes a synthetic tendon. Together these features allow the stiff yet flexible pad to “drape” over a surface to maximize contact.” Another example of current nanotechnology too cool to ignore is provided by a card-sized adhesive that can support up to 700 pounds on a glass surface, be easily released, and reused many times. A hat tip to ScienceDaily for reprinting this UMass Amherst news release “ Inspired by gecko feet, UMass Amherst scientists invent super-adhesive material “: For years, biologists have been amazed by the power of gecko feet, which let these 5-ounce lizards produce an adhesive force roughly equivalent to carrying nine pounds up a wall without slipping. Now, a team of polymer scientists and a biologist at the University of Massachusetts Amherst have discovered exactly how the gecko does it, leading them to invent “Geckskin,” a device that can hold 700 pounds on a smooth wall. Doctoral candidate Michael Bartlett in Alfred Crosby’s polymer science and engineering lab at UMass Amherst is the lead author of their article describing the discovery in the current online issue of Advanced Materials [ abstract ]. The group includes biologist Duncan Irschick, a functional morphologist who has studied the gecko’s climbing and clinging abilities for over 20 years. Geckos are equally at home on vertical, slanted, even backward-tilting surfaces. “Amazingly, gecko feet can be applied and disengaged with ease, and with no sticky residue remaining on the surface,” Irschick says. These properties, high-capacity, reversibility and dry adhesion offer a tantalizing possibility for synthetic materials that can easily attach and detach heavy everyday objects such as televisions or computers to walls, as well as medical and industrial applications, among others, he and Crosby say. This combination of properties at these scales has never been achieved before, the authors point out. Crosby says, “Our Geckskin device is about 16 inches square, about the size of an index card, and can hold a maximum force of about 700 pounds while adhering to a smooth surface such as glass.” Beyond its impressive sticking ability, the device can be released with negligible effort and reused many times with no loss of effectiveness. For example, it can be used to stick a 42-inch television to a wall, released with a gentle tug and restuck to another surface as many times as needed, leaving no residue. Previous efforts to synthesize the tremendous adhesive power of gecko feet and pads were based on the qualities of microscopic hairs on their toes called setae, but efforts to translate them to larger scales were unsuccessful, in part because the complexity of the entire gecko foot was not taken into account. As Irschick explains, a gecko’s foot has several interacting elements, including tendons, bones and skin, that work together to produce easily reversible adhesion. Now he, Bartlett, Crosby and the rest of the UMass Amherst team have unlocked the simple yet elegant secret of how it’s done, to create a device that can handle excessively large weights. Geckskin and its supporting theory demonstrate that setae are not required for gecko-like performance, Crosby points out. “It’s a concept that has not been considered in other design strategies and one that may open up new research avenues in gecko-like adhesion in the future.” The key innovation by Bartlett and colleagues was to create an integrated adhesive with a soft pad woven into a stiff fabric, which allows the pad to “drape” over a surface to maximize contact. Further, as in natural gecko feet, the skin is woven into a synthetic “tendon,” yielding a design that plays a key role in maintaining stiffness and rotational freedom, the researchers explain. Importantly, the Geckskin’s adhesive pad uses simple everyday materials such as polydimethylsiloxane (PDMS), which holds promise for developing an inexpensive, strong and durable dry adhesive. An amazing example of how controlling structure at the nanometer scale can provide very substantial forces at the macroscopic scale. —James Lewis, PhD

Nanotechnology-based sensor does rapid reads of single DNA molecule

Photo and description courtesy of University of Washington “The various levels of electrical signal from the sequence of a DNA strand pulled through a nanopore reader (top) corresponds to specific DNA nucleotides, thymine, adenine, cytosine and guanine (bottom).” We recently noted the contribution of nanotechnology-based DNA sequencing methods to research and to the emerging field of personalized medicine. Another major step along this path was taken more recently by combining a mutated protein pore with a DNA polymerase molecular motor. A hat tip to ScienceDaily for reprinting this University of Washington news release written by Vince Stricherz “ Tiny reader makes fast, cheap DNA sequencing feasible “: Researchers have devised a nanoscale sensor to electronically read the sequence of a single DNA molecule, a technique that is fast and inexpensive and could make DNA sequencing widely available. The technique could lead to affordable personalized medicine, potentially revealing predispositions for afflictions such as cancer, diabetes or addiction. “There is a clear path to a workable, easily produced sequencing platform,” said Jens Gundlach, a University of Washington physics professor who leads the research team. “We augmented a protein nanopore we developed for this purpose with a molecular motor that moves a DNA strand through the pore a nucleotide at a time.” The researchers previously reported creating the nanopore by genetically engineering a protein pore from a mycobacterium. The nanopore, from Mycobacterium smegmatis porin A, has an opening 1 billionth of a meter in size, just large enough for a single DNA strand to pass through. To make it work as a reader, the nanopore was placed in a membrane surrounded by potassium-chloride solution, with a small voltage applied to create an ion current flowing through the nanopore. The electrical signature changes depending on the type of nucleotide traveling through the nanopore. Each type of DNA nucleotide – cytosine, guanine, adenine and thymine – produces a distinctive signature. The researchers attached a molecular motor, taken from an enzyme associated with replication of a virus, to pull the DNA strand through the nanopore reader. The motor was first used in a similar effort by researchers at the University of California, Santa Cruz, but they used a different pore that could not distinguish the different nucleotide types. Gundlach is the corresponding author of a paper published online March 25 by Nature Biotechnology [ abstract ] that reports a successful demonstration of the new technique using six different strands of DNA. The results corresponded to the already known DNA sequence of the strands, which had readable regions 42 to 53 nucleotides long. “The motor pulls the strand through the pore at a manageable speed of tens of milliseconds per nucleotide, which is slow enough to be able to read the current signal,” Gundlach said. Gundlach said the nanopore technique also can be used to identify how DNA is modified in a given individual. Such modifications, referred to as epigenetic DNA modifications, take place as chemical reactions within cells and are underlying causes of various conditions. “Epigenetic modifications are rather important for things like cancer,” he said. Being able to provide DNA sequencing that can identify epigenetic changes “is one of the charms of the nanopore sequencing method.” The ability to identify epigenetic modifications (mostly methylations of specific nucleotides) is indeed a plus, although we can hope that with further development the technology will be able to read DNA sequences far longer than 42 to 53 nucleotides. Because repeating sequences are prevalent in the human genome, the ability to do long reads is very important. —James Lewis, PhD

Adding to the toolbox for making complex molecular machines

As synthetic biology seeks to build ever more complex biological machines, the possibility of a bridge from biological to artificial molecular machine systems grows less far-fetched. Recent advances in yeast molecular biology are leading to the ability to make more complex molecular machines in yeast, substantially augmenting the synthetic biology toolkit. A hat tip to ScienceDaily for reprinting this AlphaGalileo news release from Imperial College London: “ Scientists develop tools to make more complex biological machines from yeast “: Scientists are one step closer to making more complex microscopic biological machines, following improvements in the way that they can “re-wire” DNA in yeast, according to research published today in the journal PLoS ONE [ open access article ]. The researchers, from Imperial College London, have demonstrated a way of creating a new type of biological “wire”, using proteins that interact with DNA and behave like wires in electronic circuitry. The scientists say the advantage of their new biological wire is that it can be re-engineered over and over again to create potentially billions of connections between DNA components. Previously, scientists have had a limited number of “wires” available with which to link DNA components in biological machines, restricting the complexity that could be achieved. The team has also developed more of the fundamental DNA components, called “promoters”, which are needed for re-programming yeast to perform different tasks. Scientists currently have a very limited catalogue of components from which to engineer biological machines. By enlarging the components pool and making it freely available to the scientific community via rapid Open Access publication, the team in today’s study aims to spur on development in the field of synthetic biology. Future applications of this work could include tiny yeast-based machines that can be dropped into water supplies to detect contaminants, and yeast that records environmental conditions during the manufacture of biofuels to determine if improvements can be made to the production process. Dr Tom Ellis, senior author of the paper from the Centre for Synthetic Biology and Innovation and the Department of Bioengineering at Imperial College London, says: “From viticulture to making bread, humans have been working with yeast for thousands of years to enhance society. Excitingly, our work is taking us closer to developing more complex biological machines with yeast. These tiny biological machines could help to improve things such as pollution monitoring and cleaner fuels, which could make a difference in all our lives.” Dr Benjamin Blount, first author of the paper from the Centre for Synthetic Biology and Innovation and the Department of Bioengineering at Imperial College London, says: “Our new approach to re-wiring yeast opens the door to an exciting array of more complex biological devices, including cells engineered to carry out tasks similar to computers.” In the study, the Imperial researchers modified a protein-based technology called TAL Effectors, which produce TALOR proteins, with similar qualities to wires in electronic devices. These TALORS can be easily re-engineered, which means that they can connect with many DNA-based components without causing a short circuit in the device. The team says their research now provides biological engineers working in yeast with a valuable new toolbox. Professor Richard Kitney, Co-Director of the Centre for Synthetic Biology and Innovation at the College, adds: “The work by Dr Ellis and the team at the Centre really takes us closer to developing much more complex biological machines with yeast, which may help to usher in a new age where biological machines could help to improve our health, the way we work, play and live.” Professor Paul Freemont, Co-Director of the Centre for Synthetic Biology and Innovation at the College, concludes: “One of the core aims of the Centre is to provide tools and resources to the wider scientific community by sharing our research. Dr Ellis’s team has now begun to assemble characterised biological parts for yeast that will be available to researchers both in academia and industry.” Promoters are DNA sequences that signal transcription of a gene to make a messenger RNA molecule that is then translated to make the protein product encoded by the gene. By systematically mutagenizing the core sequence of one promoter, the researchers created a library of 36 promoters that could be independently regulated. They also created a library of proteins to specifically turn off individual variant promoters. They thus designed a complex network of gene regulation that can be used for arbitrary engineering purposes rather than those networks that have evolved to fit the yeast’s own metabolic needs. One wonderful aspect of this work is that, not only are the results published in an open access journal rather than sequestered behind a pay wall, but the biological “parts” created are available to other biological engineers to elaborate the toolbox that is available to synthetic biology and, perhaps eventually, for a folded polymer path toward productive nanosystems. IMHO, this collaborative “Open Source-like” approach being pursued in synthetic biology provides an admirable paradigm for the development of advanced nanotechnology. —James Lewis, PhD

Designer Electrons with Tunable Properties

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Nanopore in Graphene may provide Ultrafast Inexpensive DNA Sequencing

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Graphene Nanosheets to be produced cost effectively

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Atomically-precise positioning of a single atom transistor-VIDEO

A team led by Michelle Y. Simmons, who spoke on “Atomic-scale device fabrication in silicon” at the 2007 Productive Nanosystems: Launching the Technology Roadmap conference, which introduced the Technology Roadmap for Productive Nanosystems , has succeeded in the atomically precise placement of a transistor consisting of a single atom of phosphorous between source and drain electrodes and gate electrodes all made from phosphorous wires only a few atoms wide. A YouTube video illustrating this working transistor of a single atom of phosphorous placed with atomic precision on a silicon crystal includes an STM image that shows the single phosphorous atom placed several tens of rows of silicon atoms from source and drain electrodes of phosphorous that appear to be about 10 rows of atoms wide. To manufacture the phosphorous transistor and electrodes, a scanning tunneling microscope was used to remove precisely determined hydrogen atoms from the passivating layer covering a silicon crystal to form a mask that was then used to apply phosphorous atoms to the vacancies created. An overlay of silicon atoms then preserved these phosphorous nanostructures. The accomplishment is described in a NY Times article by John Markoff, which describes both the place of this work in the progression of Moore’s Law and its potential for a new generation of quantum computers: “ Physicists Create a Working Transistor From a Single Atom “: Australian and American physicists have built a working transistor from a single phosphorus atom embedded in a silicon crystal. The group of physicists, based at the University of New South Wales and Purdue University, said they had laid the groundwork for a futuristic quantum computer that might one day function in a nanoscale world and would be orders of magnitude smaller and quicker than today’s silicon-based machines. … “Their approach is extremely powerful,” said Andreas Heinrich, an I.B.M. physicist. “This is at least a 10-year effort to make very tiny electrical wires and combine them with the placement of a phosphorous atom exactly where they want them.” He said the research was a significant step toward making a functioning quantum computing system. However, whether quantum computing will ever be harnessed for useful tasks remains uncertain, and the researchers also noted that their work demonstrated the fundamental limits that today’s computers would be able to shrink to. “It shows that Moore’s Law can be scaled toward atomic scales in silicon,” said Gerhard Klimeck, professor of electrical and computer engineering at Purdue, referring to the rate at which computing gets faster and cheaper. “The technologies for classical computing can survive to the atomic scale.” The results were published in Nature Nanotechnology [ abstract ]. At least for the moment (February 19, 2012), the full text is available without charge. Also available in the same issue is a commentary by Gabriel P. Lansbergen “ Nanoelectronics: Transistors arrive at the atomic limit “, which gives additional background and details on this accomplishment. … Single-atom transistors represent the ultimate limit in solid-state device miniaturization, but they are also interesting for another reason. Deterministically positioned single-dopant atoms in silicon, electrically addressable by metallic leads, are at the heart of a number of promising proposals for quantum-information-processing devices3. The long coherence and relaxation times associated with single dopants make them very attractive candidates for quantum-device architectures. The atom-by-atom fabrication technique developed by Simmons and co-workers therefore fulfills a long-standing need for a method that is capable of atomic-scale device fabrication in silicon. And although the technique is not directly applicable on an industrial scale, it does bring the development of truly atomistic electronics — and the possibilities they offer — into the experimental realm. This latest accomplishment from Prof. Simmons and her collaborators follows swiftly on their recent demonstration published just last month in Science [ abstract ], that Ohms law holds for nanowire only four phosphorous atoms wide. From the Purdue University news service “ Down to the wire for silicon: Researchers create a wire 4 atoms wide, 1 atom tall “: The smallest wires ever developed in silicon – just one atom tall and four atoms wide – have been shown by a team of researchers from the University of New South Wales, Melbourne University and Purdue University to have the same current-carrying capability as copper wires. Experiments and atom-by-atom supercomputer models of the wires have found that the wires maintain a low capacity for resistance despite being more than 20 times thinner than conventional copper wires in microprocessors. The discovery, which was published in this week’s journal Science, has several implications, including: For engineers it could provide a roadmap to future nanoscale computational devices where atomic sizes are at the end of Moore’s law. The theory shows that a single dense row of phosphorus atoms embedded in silicon will be the ultimate limit of downscaling. For computer scientists, it places donor-atom based silicon quantum computing closer to realization. And for physicists, the results show that Ohm’s Law, which demonstrates the relationship between electrical current, resistance and voltage, continues to apply all the way down to an atomic-scale wire. … Although the path from this laboratory demonstration to a practical technology is not yet clear, as emphasized above by the researchers themselves and commentators, the progress at Zyvex Labs (and elsewhere) that we cited in Oct. 2010 in this basic technology of using an STM for atomically precise lithography holds hope that a convergence of manufacturing technology and demonstrated prototypes will not be too distant. —James Lewis